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Submit ReviewDOB hydrochloride
Description: Selective 5-HT2 agonist
Alternative Names: 2,5-Dimethoxy-4-bromoamphetamine hydrochloride
Chemical Name: 4-Bromo-2,5-dimethoxy-α-methylbenzeneethanamine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for DOB hydrochloride
Selective 5-HT2 receptor agonist (Ki values are 0.44, 59, 69, 831 and 3700 nM for 5-HT2H, 5-HT2L, 5-HT2C, 5-HT1B and 5-HT1A receptors respectively). Hallucinogenic.
Technical Data for DOB hydrochloride
| M. Wt | 310.62 |
| Formula | C11H16BrNO2.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 29705-96-2 |
| PubChem ID | 12626562 |
| InChI Key | SPBBKPOIDQIWDZ-UHFFFAOYSA-N |
| Smiles | BrC1=C(OC)C=C(CC(C)N)C(OC)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for DOB hydrochloride
References for DOB hydrochloride
References are publications that support the biological activity of the product.
Titiler et al (1987) Selectivity of serotonergic drugs for multiple brain serotonin receptors. Biochem.Pharmacol. 36 3265 PMID: 3663239
Arvanov et al (1999) A pre- and postsynaptic modulatory action of 5-HT and the 5-HT2A,2C receptor agonist DOB on NMDA-evoked responses in the rat medial prefrontal cortex. Eur.J.Neurosci. 11 2917 PMID: 10457188
McKenna et al (1989) Differentiation of 5-hydroxytryptamine2 receptor subtypes using 125I-R-(-)2,5-dimethoxy-4-iodo-phenylisopropylamine and 3H-ketanserin. J.Neurosci. 10 3482
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Citations for DOB hydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.